1/11/2024 0 Comments Low end tidal co2![]() ![]() Several studies have tried to find the optimal tidal volume during mechanical ventilation to protect the lung in various clinical situations. In conclusion, the RR required to get the target ETCO 2 was much lower in children patients taking antiepileptic drugs than that of non-user children patients during the general anesthesia.ĭuring general anesthesia, it is essential to control and monitor the ventilation status by using the respiratory rate (RR), tidal volume, end-tidal carbon dioxide (ETCO 2), and oxygenation. The C e50 and ETCO 2 data fit to a sigmoid E max model. The values of γ (the steepness of the concentration-response relation curve) and k eo (the first-order rate constant determining the equilibration between the RR and ETCO 2) were 7.53 and 0.467 min -1, respectively. 35 mmHg) was 20.5 in non-users of antiepileptic drugs and 14.9 in those on antiepileptic drug medication. The C e50 (RR to achieve 50% of maximum decrease in ETCO 2 i.e. Hysteresis between the RR and ETCO 2 was observed and accounted for when the model was developed. As RR varied from 3 to 37 breaths per minute, the ETCO 2 changed from 40 to 30 mmHg. Pharmacodynamic analysis using a sigmoid E max model was performed to assess the RR-ETCO 2 relationship. When the ETCO 2 was at 40 mmHg, the RR was adjusted 1 breath per every 2 min until the ETCO 2 was 30 mmHg and recovered to 40 mmHg. A prospective observational study was designed to include 51 patients (aged ≤ 12 years), including users of antiepileptic drugs (levetiracetam, valproic, or phenobarbital ( n = 21)) and non-users ( n = 30), scheduled to receive general anesthesia during elective surgery. For the purpose of this study, we used a population pharmacodynamic modeling approach to establish the relationship between RR versus ETCO 2 data during general anesthesia in children, and to identify the clinical variables affecting this relationship. It is essential to monitor the end-tidal carbon dioxide (ETCO 2) during general anesthesia and adjust the tidal volume and respiratory rate (RR). ![]()
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